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Stuart Hesketh

Senior Lecturer

Skeletal Muscle, Exercise Physiology, Proteomics, Circadian Biology, Exercise Biochemistry, Sports & Exercise Science

I have particular expertise in a broad range of Sports and Exercise Science related disciplines. This ranges from the application of S&C applied principles to lab-based Molecular Exercise Physiology. My research focuses on the molecular mechanisms underpinning skeletal muscle adaptation and loss in response to exercise, with a particular emphasis on circadian biology, ageing, and health. I apply advanced mass spectrometry-based proteomics and molecular physiology techniques to explore how exercise training regulates protein synthesis, degradation, and homeostasis within a health and exercise context. I completed my PhD at the Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, supported by a fully funded scholarship, where I worked in Prof. Jatin Burnismore...

PhD, Muscle Proteomics and Physiology, Liverpool John Moores University, 2019 MSc, Sport and Exercise Physiology, Liverpool John Moores University, 2015 PGCE, Post-compulsory Education and Training, Edge Hill University, 2013 BSc (Hons), Sport and Exercise Science, Edge Hill University, 2012

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Latest Additions

  1. Wolff, Christopher, Gutierrez-Monreal, Miguel A., Meng, Lingsong, Zhang, Xiping, Douma, Lauren G., Costello, Hannah M., Douglas, Collin M., Ebrahimi, Elnaz, Pham, Ann et al (2023) Defining the age-dependent and tissue-specific circadian transcriptome in male mice. Cell Reports, 42 (1). ISSN 2211-1247
  2. Wolff, Christopher A., Hesketh, Stuart orcid iconORCID: 0000-0001-7855-2380 and Esser, Karyn A. (2022) Circadian Rhythms and Exercise Metabolism. In: Exercise Metabolism. Springer, p. 357.
  3. Hesketh, Stuart J orcid iconORCID: 0000-0001-7855-2380, Douglas, Colin and Esser, Karyn (2021) Time of Day and Muscle Strength: A Circadian Output? Physiology (Bethesda, Md.) .
  4. Hesketh, Stuart J orcid iconORCID: 0000-0001-7855-2380, Stansfield, Ben, Stead, Connor and Burniston, Jatin (2021) The application of proteomics in muscle exercise physiology. Expert Review of Proteomics, 17 (11-12). pp. 813-825.
  5. Hesketh, Stuart orcid iconORCID: 0000-0001-7855-2380, Sutherland, Hazel, Lisboa, Paulo, Jarvis, Jonathan and Burniston, Jatin (2020) Adaptation of rat fast‐twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis. The FASEB Journal .
  6. Stead, Connor, Hesketh, Stuart orcid iconORCID: 0000-0001-7855-2380, Bennett, Sam, Surtherland, Hazel, Jarvis, Jonathan, Lisboa, Paulo and Burniston, Jatin (2020) Fractional Synthesis Rates of Individual Proteins in Rat Soleus and Plantaris Muscles. Proteomes .
  7. Hesketh, Stuart J orcid iconORCID: 0000-0001-7855-2380, Srisawat, Kanchana, Sutherland, Hazel, Jarvis, Jonathan and Burniston, Jatin (2016) On the Rate of Synthesis of Individual Proteins within and between Different Striated Muscles of the Rat. Proteomes .
  8. Hesketh, Stuart orcid iconORCID: 0000-0001-7855-2380, Sexton, Casey, Wolff, Chris, Viggars, Mark and Esser, Karyn (2023) Early morning run-training results in enhanced endurance performance adaptations in mice. The Journal of Physiology . ISSN 0022-3751 (Submitted)
  9. Hesketh, Stuart J orcid iconORCID: 0000-0001-7855-2380 (2024) Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine. Sports Medicine and Health Science, 6 (1). pp. 1-15.
  10. Viggars, Mark R., Berko, Hannah, Hesketh, Stuart orcid iconORCID: 0000-0001-7855-2380, Wolff, Christopher A., Gutierrez-Monreal, Miguel A., Martin, Ryan A., Jennings, Isabel G., Huo, Zhiguang and Esser, Karyn A. (2024) Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training. Molecular Metabolism, 86 .