Items created by jhayes@uclan.ac.uk

Article

Emmerich, Thomas D, Taylor-Chilton, Eleanor, Caballero, Elena, Hushcha, Iryna, Dickens, Kathryn ORCID: 0000-0003-0925-1538, Stasik, Izabela ORCID: 0000-0002-7756-4731, Alder, Jane Elizabeth ORCID: 0000-0003-4463-0349, Saavedra-Castano, Santiago, Berenschot, Erwin et al (2025) Structure-Based Discovery Targeting GSK-3α Reveals Potent Nanomolar Selective 4-Phenyl-1H-benzofuro[3,2-b]pyrazolo[4,3-e]pyridine Inhibitor with Promising Glioblastoma and CNS-Active Potential in Cellular Models. Journal of Medicinal Chemistry, 68 (8). pp. 8679-8693. ISSN 0022-2623

Schram, Niah, Hayes, Joseph ORCID: 0000-0002-7745-9616, Antia, Imeobong ORCID: 0000-0001-6620-1903 and Stasik, Izabela ORCID: 0000-0002-7756-4731 (2024) STUDIES ON GLYCOGEN PHOSPHORYLASE AS A POTENTIAL MOLECULAR TARGET IN GLIOBLASTOMA. Neuro-Oncology, 26 (Supp7). vii17-vii17. ISSN 1522-8517

Khan, Zahra Rafiqa, Welsby, Philip J., Stasik, Izabela ORCID: 0000-0002-7756-4731 and Hayes, Joseph ORCID: 0000-0002-7745-9616 (2024) Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma. Journal of Medicinal Chemistry, 67 (9). pp. 7539-7552. ISSN 0022-2623

Khan, Zahra, Stasik, Izabela ORCID: 0000-0002-7756-4731 and Hayes, Joseph ORCID: 0000-0002-7745-9616 (2022) Computer-aided Design of Novel CDK5 Inhibitors; Towards New Treatments of Glioblastoma. Neuro-Oncology, 24 (Supple). iv8-iv8. ISSN 1523-5866

Rzepecka, Klaudia, Lawrence, Clare Louise ORCID: 0000-0003-0170-0079, Moualla, Dima, Hayes, Joseph ORCID: 0000-0002-7745-9616 and Alder, Jane Elizabeth ORCID: 0000-0003-4463-0349 (2022) Effects of Glycogen Synthase Kinase-3β (GSK3β) Inhibition in Glioblastoma Using Novel Compounds. Neuro-Oncology, 24 (Supple). iv20-iv20. ISSN 1523-5866

Sullivan, Mark Vincent, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Hayes, Joseph ORCID: 0000-0002-7745-9616 and Reddy, Subrayal M ORCID: 0000-0002-7362-184X (2021) Evaluation of acrylamide-based molecularly imprinted polymer thin-sheets for specific protein capture - a myoglobin model. Biomedical Physics and Engineering Express .

Sullivan, Mark, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Archontis, Georgios, Reddy, Subrayal M ORCID: 0000-0002-7362-184X and Hayes, Joseph ORCID: 0000-0002-7745-9616 (2019) Toward Rational Design of Selective Molecularly Imprinted Polymers (MIPs) for Proteins: Computational and Experimental Studies of Acrylamide Based Polymers for Myoglobin. The Journal of Physical Chemistry B, 123 (26). pp. 5432-5443. ISSN 1520-6106

Stravodimos, G, Chetter, Ben, Kyriakis, E, Kantsadi, A.L, Chatzileontiadou, D.S.M, Skamnaki, V.T, Kato, A, Hayes, Joseph ORCID: 0000-0002-7745-9616 and Leonidas, D.D (2017) Phytogenic polyphenols as glycogen phosphorylase inhibitors: The potential of triterpenes and flavonoids for glycaemic control in type 2 diabetes. Current Medicinal Chemistry, 24 (4). pp. 384-403. ISSN 0929-8673

Tsitsanou, Katerina E., Hayes, Joseph ORCID: 0000-0002-7745-9616, Keramioti, Maria, Mamais, Michalis, Oikonomakos, Nikos G., Kato, Atsushi, Leonidas, Demetres D. and Zographos, Spyros E. (2013) Sourcing the affinity of flavonoids for the glycogen phosphorylase inhibitor site via crystallography, kinetics and QM/MM-PBSA binding studies: Comparison of chrysin and flavopiridol. Food and Chemical Toxicology, 61 . pp. 14-27. ISSN 0278-6915

Hayes, Joseph ORCID: 0000-0002-7745-9616 and Leonidas, Demetres D. (2010) Computation as a tool for glycogen phosphorylase inhibitor design. Mini-Reviews in Medicinal Chemistry, 10 (12). pp. 1156-1174. ISSN 1389-5575

Wen, Xiaoan, Sun, Hongbin, Liu, Jun, Cheng, Keguang, Zhang, Pu, Zhang, Liying, Hao, Jia, Zhang, Luyong, Ni, Peizhou et al (2008) Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure−Activity Relationships, and X-ray Crystallographic Studies†. Journal of Medicinal Chemistry, 51 (12). pp. 3540-3554. ISSN 0022-2623

Hayes, Joseph ORCID: 0000-0002-7745-9616, Viciano, M., Peris, E., Ujaque, G. and Lledós, A. (2007) Mechanism of formation of silver N-heterocyclic carbenes using silver oxide: A theoretical study. Organometallics, 26 (25). pp. 6170-6183. ISSN 02767333

Norton, S.H., Bachrach, S.M. and Hayes, Joseph ORCID: 0000-0002-7745-9616 (2005) Theoretical study of nucleophilic substitution at sulfur in sulfinyl derivatives. Journal of Organic Chemistry, 70 (15). pp. 5896-5902. ISSN 00223263

Hayes, Joseph ORCID: 0000-0002-7745-9616, Stein, M. and Weiser, J. (2004) Accurate Calculations of Ligand Binding Free Energies: Chiral Separation with Enantioselective Receptors. Journal of Physical Chemistry A, 108 (16). pp. 3572-3580. ISSN 10895639

Hayes, Joseph ORCID: 0000-0002-7745-9616 and Bachrach, S.M. (2003) Effect of micro and bulk solvation on the mechanism of nucleophilic substitution at sulfur in disulfides. Journal of Physical Chemistry A, 107 (39). pp. 7952-7961. ISSN 1089-5639

Bachrach, S.M., Hayes, Joseph ORCID: 0000-0002-7745-9616, Dao, T. and Mynar, J.L. (2002) Density functional theory gas- and solution-phase study of nucleophilic substitution at di- and trisulfides. Theoretical Chemistry Accounts, 107 (5). pp. 266-271. ISSN 1432881X

Bachrach, S.M., Hayes, Joseph ORCID: 0000-0002-7745-9616, Check, C.E. and Sunderlin, L.S. (2001) Potential energy surface of SOCl3 -. Journal of Physical Chemistry A, 105 (41). pp. 9595-9597. ISSN 10895639

Book Section

Hayes, Joseph ORCID: 0000-0002-7745-9616 (2016) Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products. In: Discovery and Development of Antidiabetic Agents from Natural Products: Natural Product Drug Discovery. Elsevier, pp. 29-62. ISBN 9780128094501