Items created by Snape, Timothy James

2020

Chetter, Ben, Kyriakis, Efthimios, Barr, Daniel, Karra, Aikaterini G., Katsidou, Elisabeth, Koulas, Symeon M., Skamnaki, Vassiliki T., Snape, Timothy James ORCID: 0000-0003-2766-4491, Psarra, Anna-Maria G. et al (2020) Synthetic flavonoid derivatives targeting the glycogen phosphorylase inhibitor site: QM/MM-PBSA motivated synthesis of substituted 5,7-dihydroxyflavones, crystallography, in vitro kinetics and ex-vivo cellular experiments reveal novel potent inhibitors. Bioorganic Chemistry, 102 (104003). ISSN 0045-2068

2019

Barr, Daniel, Szennyes, Eszter, Bokor, Éva, Al-Oanzi, Ziad H., Moffatt, Colin, Kun, Sándor, Docsa, Tibor, Sipos, Ádám, Davies, Matthew et al (2019) Identification of C-β-d-Glucopyranosyl Azole-Type Inhibitors of Glycogen Phosphorylase That Reduce Glycogenolysis in Hepatocytes: In Silico Design, Synthesis, in Vitro Kinetics, and ex Vivo Studies. ACS Chemical Biology, 14 (7). pp. 1460-1470. ISSN 1554-8929

2018

Sherer, Christopher ORCID: 0000-0002-6422-9870, Prabhu, Saurabh, Adams, David R, Hayes, Joseph ORCID: 0000-0002-7745-9616, Rowther, Farzana, Tolaymat, Ibrahim, Warr, Tracy and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2018) Towards identifying potent new hits for glioblastoma. MedChemComm, 9 (11). pp. 1850-1861. ISSN 2040-2503

2017

Sherer, Christopher ORCID: 0000-0002-6422-9870, Tolaymat, Ibrahim, Rowther, Farzana, Warr, Tracy and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2017) Preliminary SAR on indole-3-carbinol and related fragments reveals a novel anticancer lead compound against resistant glioblastoma cells. Bioorganic & Medicinal Chemistry Letters, 27 (7). pp. 1561-1565. ISSN 0960-894X

2016

Snape, Timothy James ORCID: 0000-0003-2766-4491, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607 and Patil--sen, Yogita ORCID: 0000-0002-4286-8874 (2016) Functional foldamers that target bacterial membranes: the effect of charge, amphiphilicity and conformation. Bioorganic & Medicinal Chemistry, 24 (18). pp. 4241-4245. ISSN 0968-0896

Harris, Frederick, Prabhu, Saurabh, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Snape, Timothy James ORCID: 0000-0003-2766-4491, Lea, Robert William, Mura, Manuela and Phoenix, David Andrew (2016) Anionic Host Defence Peptides from the Plant Kingdom: Their Anticancer Activity and Mechanisms of Action. Protein and Peptide Letters, 23 (8). pp. 676-687. ISSN 0929-8665

2015

Fahs, Sara, Patil-Sen, Yogita ORCID: 0000-0002-4286-8874 and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2015) Foldamers as Anticancer Therapeutics: Targeting Protein-Protein Interactions and the Cell Membrane. ChemBioChem, 16 (13). pp. 1840-1853. ISSN 14394227

Hester, Theodore James, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Baker, Matthew ORCID: 0000-0003-2362-8581 and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2015) Functionalising the azobenzene motif delivers a light-responsive membrane-interactive compound with the potential for photodynamic therapy applications. Organic Biomolecular Chemistry, 13 (29). pp. 8067-8070. ISSN 1477-0520

Sherer, Chris and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2015) Heterocyclic scaffolds as promising anticancer agents against tumours of the central nervous system: Exploring the scope of indole and carbazole derivatives. European Journal of Medicinal Chemistry, 97 . pp. 552-560. ISSN 02235234

Ameen, Dana and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2015) A Baker–Venkataraman retro-Claisen cascade delivers a novel alkyl migration process for the synthesis of amides. Tetrahedron Letters, 56 (14). pp. 1816-1819. ISSN 00404039

2014

Snape, Timothy J. ORCID: 0000-0003-2766-4491 and Warr, Tracy (2014) Approaches Toward Improving the Prognosis of Pediatric Patients With Glioma: Pursuing Mutant Drug Targets With Emerging Small Molecules. Seminars in Pediatric Neurology, 22 (1). pp. 28-34.

Prabhu, Saurabh, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Mura, Manuela ORCID: 0000-0002-3913-7595, Lea, Robert William, Snape, Timothy James ORCID: 0000-0003-2766-4491 and Harris, Frederick (2014) Cn-AMP2 from green coconut water is an anionic anticancer peptide. Journal of Peptide Science, 20 (12). pp. 909-915. ISSN 1075-2617

Snape, Timothy James ORCID: 0000-0003-2766-4491, Fahs, Sara, Rowther, Farjana, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Patil-Sen, Yogita and Warr, Tracy (2014) Development of a novel, multifunctional, membrane-interactive pyridinium salt with potent anticancer activity. Bioorganic & Medicinal Chemistry Letters, 24 (15). pp. 3430-3433. ISSN 0960-894X

Ameen, Dana and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2014) Developing the Scope of O→C Aryl Migrations: Exploring Amide Substrates as Potential Precursors for Asymmetric Reactions. European Journal of Organic Chemistry, 2014 (9). pp. 1925-1934. ISSN 1434-193X

Lal, Samridhi and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2014) Aromatic amides and ureas as novel molecular probes for diagnosing disease. Medical Hypotheses, 83 (6). pp. 751-754. ISSN 03069877

Snape, Timothy James ORCID: 0000-0003-2766-4491 and Ameen, Dana (2014) Mechanism and Application of Baker–Venkataraman O→C Acyl Migration Reactions. Synthesis, 47 (02). pp. 141-158. ISSN 0039-7881

Prabhu, Saurabh, Harris, Frederick, Lea, Robert William and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2014) Small-molecule clinical trial candidates for the treatment of glioma. Drug Discovery Today, 19 (9). pp. 1298-1308. ISSN 13596446

2013

Prabhu, Saurabh, Dennison, Sarah R., Lea, Bob, Snape, Timothy J. ORCID: 0000-0003-2766-4491, Nicholl, Iain D., Radecka, Iza and Harris, Frederick (2013) Anionic Antimicrobial and Anticancer Peptides from Plants. Critical Reviews in Plant Sciences, 32 (5). pp. 303-320. ISSN 0735-2689

Ameen, Dana and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2013) Chiral 1,1-diaryl compounds as important pharmacophores. MedChemComm, 4 (6). p. 893. ISSN 2040-2503

Prabhu, Saurabh, Akbar, Zaheer, Harris, Frederick, Karakoula, Katherine, Lea, Robert, Rowther, Farzana, Warr, Tracy and Snape, Timothy ORCID: 0000-0003-2766-4491 (2013) Preliminary biological evaluation and mechanism of action studies of selected 2-arylindoles against glioblastoma. Bioorganic & Medicinal Chemistry, 21 (7). pp. 1918-1924. ISSN 09680896

Dennison, Sarah R., Phoenix, David A. and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2013) Synthetic oligoureas of metaphenylenediamine mimic host defence peptides in their antimicrobial behaviour. Bioorganic & Medicinal Chemistry Letters, 23 (9). pp. 2518-2521. ISSN 0960894X

2012

Lal, Samridhi and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2012) Exploitation of a Candida antarctica lipase B-catalysed in situ carboxylic acid activation method for the synthesis of acetanilides. Journal of Molecular Catalysis B: Enzymatic, 83 . pp. 80-86. ISSN 13811177

Snape, Timothy J. ORCID: 0000-0003-2766-4491, Karakoula, Katherine, Rowther, Farzana and Warr, Tracy (2012) Exploiting conformationally restricted N,N′-dimethyl-N,N′-diarylureas as biologically active CC double bond analogues: synthesis and biological evaluation of combretastatin A-4 analogues. RSC Advances, 2 (19). p. 7557. ISSN 2046-2069

Dennison, Sarah R., Akbar, Zaheer, Phoenix, David A. and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2012) Interactions between suitably functionalised conformationally distinct benzanilides and phospholipid monolayers. Soft Matter, 8 (11). p. 3258. ISSN 1744-683X

Snape, Timothy ORCID: 0000-0003-2766-4491, March-Cortijos, Andrea and Turner, Nicholas (2012) Synthesis of 1,3-Disubstituted Azetidines via a Tandem Ring-Opening Ring-Closing Procedure. Synlett, 23 (10). pp. 1511-1515. ISSN 0936-5214

Dennison, Sarah R., Snape, Timothy J. ORCID: 0000-0003-2766-4491 and Phoenix, David A. (2012) Thermodynamic interactions of a cis and trans benzanilide with Escherichia coli bacterial membranes. European Biophysics Journal, 41 (8). pp. 687-693. ISSN 0175-7571

2011

Harris, Frederick, Prabhu, Saurabh, Lea, Robert William and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2011) Characterisation of an anionic antimicrobial peptide isolated from green coconut water. In: UK-Netherlands Joint Symposium on Antimicrobial peptides: Isolation, characterization, modification and applications, 2011, University of Durham.

Prabhu, Saurabh, Harris, Frederick, Lea, Robert William and Snape, Timothy James ORCID: 0000-0003-2766-4491 (2011) Towards establishing the effects and mechanism of action of a series of substituted indoles in an in vitro chemosensitivity system for glioma treatment. In: Britsh Neuro-Oncology Annual Meeting, 2011, University of Glagow.

2009

Ellis, Andrew J, Reiss, Renate, Snape, Timothy James ORCID: 0000-0003-2766-4491 and Turner, Nicholas (2009) Monoamine oxidase (MAO-N) catalysed reactions: application towards the chemo-enzymatic deracemisation of the alkaloid (+)- crispine A. In: Practical methods for biocatalysis and biotransformations. Wiley, London, pp. 319-322. ISBN 0470519274

March-Cortijos, Andrea and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2009) Towards a chemo-enzymatic method for the asymmetric synthesis of β-amino tertiary alcohols. Organic & Biomolecular Chemistry, 7 (24). pp. 5163-5165. ISSN 1477-0520

March-Cortijos, Andrea and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2009) Towards a chemo-enzymatic method for the asymmetric synthesis of β-amino tertiary alcohols. Organic & Biomolecular Chemistry, 7 (24). p. 5163. ISSN 1477-0520

Deplanche, K, Snape, Timothy James ORCID: 0000-0003-2766-4491, Hazrati, S., Harrad, S. and Macaskie, L. E. (2009) Versatility of a new bioinorganic catalyst: Palladized cells of Desulfovibrio desulfuricans and application to dehalogenation of flame retardant materials. Environmental Technology, 30 (7). p. 681. ISSN 0959-3330

Deplanche, K., Snape, T.J. ORCID: 0000-0003-2766-4491, Hazrati, S., Harrad, S. and Macaskie, L.E. (2009) Versatility of a new bioinorganic catalyst: Palladized cells ofDesulfovibrio desulfuricansand application to dehalogenation of flame retardant materials. Environmental Technology, 30 (7). pp. 681-692. ISSN 0959-3330

2008

Clayden, Jonathan, Lemiègre, Loïc, Morris, Gareth A., Pickworth, Mark, Snape, Timothy J. ORCID: 0000-0003-2766-4491 and Jones, Lyn (2008) Helix Persistence and Breakdown in Oligoureas of Metaphenylenediamine: Apparent Diastereotopicity as a Spectroscopic Marker of Helix Length in Solution. Journal of the American Chemical Society, 130 (45). pp. 15193-15202. ISSN 0002-7863

Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2008) A truce on the Smiles rearrangement: revisiting an old reaction—the Truce–Smiles rearrangement. Chemical Society Reviews, 37 (11). pp. 2452-2458. ISSN 0306-0012

Snape, Timothy ORCID: 0000-0003-2766-4491 (2008) α-Arylation of Aryl Ketones: Expanding the Scope of the Truce-Smiles Rearrangement. Synlett, 2008 (17). pp. 2689-2691. ISSN 0936-5214

Cortijos, Andrea March and Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2008) Enzymatic desymmetrisation of (2-hydroxymethyl-oxiranyl)-methanol in organic solvents. Tetrahedron: Asymmetry, 19 (15). pp. 1761-1763. ISSN 09574166

Creamer, N.J., Deplanche, K., Snape, T.J. ORCID: 0000-0003-2766-4491, Mikheenko, I.P., Yong, P., Samyahumbi, D., Wood, J., Pollmann, K., Selenska-Pobell, S. et al (2008) A biogenic catalyst for hydrogenation, reduction and selective dehalogenation in non-aqueous solvents. Hydrometallurgy, 94 (1-4). pp. 138-143. ISSN 0304386X

2007

Betson, Mark S., Bracegirdle, Ann, Clayden, Jonathan, Helliwell, Madeleine, Lund, Andrew, Pickworth, Mark, Snape, Timothy J. ORCID: 0000-0003-2766-4491 and Worrall, Christopher P. (2007) Achieving conformational control over C?C, C?N and C?O bonds in biaryls, N,N?-diarylureas and diaryl ethers: advantages of a relay axis. Chemical Communications (7). p. 754. ISSN 1359-7345

Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2007) Recent advances in the semi-pinacol rearrangement of α-hydroxy epoxides and related compounds. Chemical Society Reviews, 36 (11). p. 1823. ISSN 0306-0012

Bailey, Kevin R., Ellis, Andrew J., Reiss, Renate, Snape, Timothy J. ORCID: 0000-0003-2766-4491 and Turner, Nicholas J. (2007) A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A. Chemical Communications (35). p. 3640. ISSN 1359-7345

2006

Snape, Timothy J. ORCID: 0000-0003-2766-4491 (2006) Application of the semi-pinacol rearrangement towards the generation of alkenyl-substituted quaternary carbon centres. Organic & Biomolecular Chemistry, 4 (22). p. 4144. ISSN 1477-0520

Ciucci, A., Gianferretti, P., Piva, R., Guyot, T., Snape, T. J. ORCID: 0000-0003-2766-4491, Roberts, S. M. and Santoro, M. G. (2006) Induction of Apoptosis in Estrogen Receptor-Negative Breast Cancer Cells by Natural and Synthetic Cyclopentenones: Role of the I B Kinase/Nuclear Factor- B Pathway. Molecular Pharmacology, 70 (5). pp. 1812-1821. ISSN 0026-895X

2004

Bickley, Jamie F, Roberts, Stanley M, Santoro, M.Gabriella and Snape, Timothy J ORCID: 0000-0003-2766-4491 (2004) Synthesis and revision of the stereochemistry of a cyclopentenone natural product isolated from ascomycete strain A23-98. Tetrahedron, 60 (11). pp. 2569-2576. ISSN 00404020

Dauvergne, Jérôme, Happe, Alan M, Jadhav, Vasudev, Justice, David, Matos, Marie-Christine, McCormack, Peter J, Pitts, Michael R, Roberts, Stanley M, Singh, Sanjay K et al (2004) Synthesis of 4-azacyclopent-2-enones and 5,5-dialkyl-4-azacyclopent-2-enones. Tetrahedron, 60 (11). pp. 2559-2567. ISSN 00404020