Response: Cut-off Values and Clinical Utility of Surrogate Markers for Insulin Resistance and Beta-Cell Function to Identify Metabolic Syndrome and Its Components among Southern Indian Adults (J Obes Metab Syndr 2020;29:281-91)

Abstract

Insulin resistance (IR) is a defining feature of obesity, type 2 diabetes mellitus, and cardiovascular diseases and a major contributing factor in metabolic syndrome (MetS).1,2 Although researchers have made tremendous progress in understanding IR, certain elements remain unclear, especially diagnosis.3 Various types of tests are available for quantitative estimation of IR, ranging from complicated, invasive, time-consuming procedures to simple blood tests using fasting samples.4 The hyperinsulinemic-euglycemic glucose
clamp is the gold standard method for determining IR but is impractical as it is both labor- and time-intensive.5 This issue has led to development of relatively simple markers for IR. In this study, we explored a variety of surrogate indices which have been currently available for estimating IR, insulin secretion, insulin sensitivity, and beta-cell function in a simplified and improved manner. We also investigated their clinical utility in and cutoff values for identifying MetS and its components. A deeper knowledge of these markers will help us better understand and manage this condition.