Items created by Singhrao, Simarjit Kaur

2023

Pisani, Flavio, Pisani, Valerio, Arcangeli, Francesca, Harding, Alice and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2023) Treponema denticola Has the Potential to Cause Neurodegeneration in the Midbrain via the Periodontal Route of Infection—Narrative Review. International Journal of Environmental Research and Public Health, 20 (11). p. 6049. ISSN 1661-7827

Pisani, Flavio, Pisani, Valerio, Arcangeli, Francesca, Harding, Alice and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2023) Locus Coeruleus Dysfunction and Trigeminal Mesencephalic Nucleus Degeneration: A Cue for Periodontal Infection Mediated Damage in Alzheimer’s Disease? International Journal of Environmental Research and Public Health, 20 (2). p. 1007. ISSN 1660-4601

2022

Kanagasingam, Shalini, von Ruhland, Christopher, Welbury, Richard ORCID: 0000-0002-9322-2440 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) Ex vivo detection of amyloid-beta in naturally formed oral biofilm. Journal of Alzheimers Disease Reports .

Kanagasingam, Shalini, von Ruhland, C, Welbury, Richard ORCID: 0000-0002-9322-2440 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) Antimicrobial, Polarizing Light, and Paired Helical Filament Properties of Fragmented Tau Peptides of Selected Putative Gingipains. Journal of Alzheimer's Disease . pp. 1-3. ISSN 1387-2877

Kanagasingam, Shalini, von Ruhland, C, Welbury, Richard ORCID: 0000-0002-9322-2440, Chukkapalli, SS and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) Porphyromonas gingivalis conditioned medium induces amyloidogenic processing of the amyloid -β precursor protein upon in vitro infection of SH-SY5Y cells. Journal of Alzheimer’s Disease Reports .

Pisani, Flavio, Pisani, Valerio, Arcangeli, Francesca, Harding, Alice and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) The Mechanistic Pathways of Periodontal Pathogens Entering the Brain: The Potential Role of Treponema denticola in Tracing Alzheimer’s Disease Pathology. International journal of environmental research and public health, 19 (5). p. 9386. ISSN 1661-7827

Harding, Alice, Robinson, Sarita Jane ORCID: 0000-0002-4237-5412, Crean, Stjohn ORCID: 0000-0001-9336-8549 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) Can Better Management of Periodontal Disease Delay the Onset and Progression of Alzheimer’s Disease? In: Advances in Alzheimer’s Disease. IOS Press, pp. 617-628.

Harding, Alice and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) Periodontitis and dementia: A bidirectional relationship? Journal of Dental Research, 101 (3). pp. 245-246. ISSN 0022-0345

Harding, Alice, Kanagasingam, Shalini, Welbury, Richard ORCID: 0000-0002-9322-2440 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2022) Periodontitis as a risk factor for Alzheimer’s disease – the experimental journey so far; with hope of therapy. In: Periodontitis. Advances in Experimental Medicine and Biology, 1373 . Springer, pp. 241-260. ISBN 978-3-030-96880-9

2021

Bahar, Bojlul ORCID: 0000-0002-7389-3650, Kanagasingam, Shalini, Tambuwala, Murtaza M, Aljabali, Alaa A A, Dillon, Stephanie ORCID: 0000-0002-3369-8199, Doaei, Saeid, Welbury, Richard ORCID: 0000-0002-9322-2440, Chukkapalli, Sasanka S and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2021) Porphyromonas gingivalis (W83) infection induces Alzheimer’s disease like pathophysiology in obese and diabetic mice. Journal of Alzheimer's Disease, 82 (3). pp. 1259-1275. ISSN 1387-2877

2020

Kanagasingam, Shalini, Chukkapalli, SS, Welbury, Richard ORCID: 0000-0002-9322-2440 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2020) Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer’s Disease. Journal of Alzheimer's Disease Reports, 4 (1). pp. 501-511. ISSN 2542-4823

Bahar, Bojlul ORCID: 0000-0002-7389-3650 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2020) An evaluation of the molecular mode of action of trans-resveratrol in the Porphyromonas gingivalis lipopolysaccharide challenged neuronal cell model. Molecular Biology Reports, 48 . pp. 147-156. ISSN 0301-4851

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2020) Low levels of salivary lactoferrin may affect oral dysbiosis and contribute to Alzheimer’s disease: A hypothesis. Medical hypotheses . ISSN 0306-9877

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2020) Interaction between genetic factors, Porphyromonas gingivalis and microglia to promote Alzheimer’s disease. Journal of Oral Microbiology, 12 (1).

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Harding, Alice (2020) Is Alzheimer's disease a polymicrobial host microbiome dysbiosis? Expert Review of Anti-infective Therapy, 18 (4). pp. 275-277. ISSN 1478-7210

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2020) Is there a link between genetic defects in the complement cascade and Porphyromonas gingivalis in Alzheimer’s disease? Journal of Oral Microbiology, 12 (1).

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2020) Porphyromonas gingivalis infection may contribute to systemic and intracerebral amyloid-beta: Implications for Alzheimer’s disease onset. Expert Review of Anti-infective Therapy, 18 (11). pp. 1063-1066. ISSN 1478-7210

2019

Siddiqui, Huma, Eribe, Emenike R. K., Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Olsen, Ingar (2019) High Throughput Sequencing Detect Gingivitis and Periodontal Oral Bacteria in Alzheimer’s Disease Autopsy Brains. Journal of Neuroscience Research, 1 (1) (3). ISSN 0360-4012

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Robinson, Sarita Jane ORCID: 0000-0002-4237-5412 and Harding, Alice (2019) The role of bacteria in personalized nutrition. In: Trends in Personalized Nutrition. Elsevier. ISBN 9780128164037

Harding, Alice and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2019) Periodontitis to dementia or converse? British Dental Journal, 226 (634). ISSN 0007-0610

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2019) Poor Oral Health and its Neurological Consequences: Mechanisms of Porphyromonas gingivalis Involvement in Cognitive Dysfunction. Current Oral Health Reports .

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Olsen, Ingar (2019) Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease. Journal of Oral Microbiology, 11 (1).

2018

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Olsen, Ingar (2018) Are Porphyromonas gingivalis Outer Membrane Vesicles Microbullets for Sporadic Alzheimer’s Disease Manifestation? Journal of Alzheimer's Disease Reports, 2 (1). pp. 219-228.

Olsen, Ingar, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Potempa, Jan (2018) Citrullination as a plausible link to periodontitis, rheumatoid arthritis, atherosclerosis and Alzheimer’s disease. Journal of Oral Microbiology, 10 (1).

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2018) Importance of heterogeneity in Porhyromonas gingivalis lipopolysaccharide lipid A in tissue specific inflammatory signaling. Journal of Oral Microbiology, 10 (1).

2017

Carter, CJ, France, James, Crean, Stjohn ORCID: 0000-0001-9336-8549 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2017) The Porphyromonas gingivalis/host interactome shows enrichment in GWASdb genes related to Alzheimer’s disease, diabetes and cardiovascular diseases. Frontiers in Aging Neuroscience, 9 (408).

Harding, Alice, Gonder, Ulrike, Robinson, Sarita Jane ORCID: 0000-0002-4237-5412, Crean, Stjohn ORCID: 0000-0001-9336-8549 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2017) Exploring the association between Alzheimer’s disease, oral health, microbial endocrinology and nutrition. Frontiers in Aging Neuroscience .

Pritchard, Anna ORCID: 0000-0002-6280-7008, Crean, Stjohn ORCID: 0000-0001-9336-8549, Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2017) Periodontitis, microbiomes and their role in Alzheimer’s disease. Frontiers in Aging Neuroscience, 9 (336).

Rokad, Farheen, Moseley, Ryan, Hardy, Rowan S, Chukkapalli, Sasanka, Crean, Stjohn ORCID: 0000-0001-9336-8549, Kesavalu, Lakshmyya and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2017) Cerebral oxidative stress and microvasculature defects in TNF-α expressing transgenic and Porphyromonas gingivalis-infected ApoE-/- mice. Journal of Alzheimer's Disease, 60 (2). pp. 359-369. ISSN 1387-2877

Olsen, Ingar, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Osmundsen, Harald (2017) Periodontitis, pathogenesis and progression: miRNA-mediated cellular responses to Porphyromonas gingivalis. Journal of Oral Microbiology, 9 (1). ISSN 2000-2297

Boaden, Elizabeth ORCID: 0000-0002-4647-6392, Lyons, Mary, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Dickinson, Hazel, Leathley, Michael John, Lightbody, Catherine Elizabeth ORCID: 0000-0001-5016-3471, McLoughlin, Alison Sarah Rachel ORCID: 0000-0001-5298-9306, Khan, Zarine Jamsher, Crean, Stjohn ORCID: 0000-0001-9336-8549 et al (2017) Oral flora in acute stroke patients: a prospective exploratory observational study. Gerodontology, 34 (3). pp. 343-356. ISSN 0734-0664

Harding, Alice, Robinson, Sarita Jane ORCID: 0000-0002-4237-5412, Crean, Stjohn ORCID: 0000-0001-9336-8549 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2017) Can better management of periodontal disease delay the onset and progression of Alzheimer’s disease? Journal of Alzheimer’s Disease, 58 (2). pp. 337-348. ISSN 1387-2877

Olsen, Ingar, Taubman, Martin A and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2017) Porphyromonas gingivalis suppresses adaptive immunity in periodontitis, atherosclerosis and Alzheimer’s disease. Journal of Oral Microbiology, 8 (1). ISSN 2000-2297

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Chukkapalli, Sasanka, Poole, Sophie, Velsko, Irina, Crean, Stjohn ORCID: 0000-0001-9336-8549 and Kesavalu, Lakshmyya (2017) Chronic Porphyromonas gingivalis infection accelerates the occurrence of age-related granules in ApoE-/- mice brains. Journal of Oral Microbiology, 9 (1). p. 1270602. ISSN 2000-2297

Poole, Sophie, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Chukkapalli, S, Rivera, M, Velsko, I, Kesavalu, L and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2017) Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains. Advances in Alzheimer's Disease, 5 . pp. 119-132. ISSN 2210-5727

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Harding, Alice, Chukkapalli, S, Olsen, I, Kesavalu, L and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2017) Apolipoprotein e Related Co-Morbidities and Alzheimer's Disease. Advances in Alzheimer's Disease, 5 . pp. 355-368. ISSN 2210-5727

Poole, Sophie, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Kesavalu, L., Curtis, M.A and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2017) Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue. In: Volume 5: Handbook of Infection and Alzheimer's Disease. Advances in Alzheimer's Disease, 5 . IOS Press, pp. 105-117.

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Kesavalu, L and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2017) Putative Association of Periodontitis with Alzheimer's Disease. In: Handbook of Infection and Alzheimer's Disease. Advances in Alzheimer's Disease, 5 . IOS Press, pp. 183-196.

2016

Lal, Sham, Pearce, Mark, Achilles-Day, Undine EM, Day, John G, Morton, Leslie Hugh Glyn, Crean, Stjohn ORCID: 0000-0001-9336-8549 and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2016) Developing an ecologically relevant heterogeneous biofilm model for dental-unit waterlines. Biofouling, 33 (1). pp. 75-87. ISSN 0892-7014

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2016) Inflammasome involvement in Alzheimer’s disease. Journal of Alzheimer’s Disease, 54 (1). pp. 45-53.

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Harding, Alice, Chukkapalli, Sasanka, Olsen, Ingar, Kesavalu, Lakshmyya and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2016) Apolipoprotein E related Co-Morbidities and Alzheimer’s disease. Journal of Alzheimer’s Disease, 51 (4). pp. 935-948. ISSN 1387-2877

Simmons, Tal Linda Ileen, Goodburn, B and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2016) Decision Tree Analysis as a Supplementary Tool to Enhance Histomorphological Differentiation when Distinguishing Human from Non-human Cranial Bone in both Burnt and Unburnt States: A feasibility study. Medicine, Science and the Law, 56 (1). pp. 36-45. ISSN 0025-8024

2015

Olsen, Ingar and Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2015) Can oral infection be a risk factor for Alzheimer’s disease? Journal of Oral Microbiology, 7 . ISSN 2000-2297

Lal, Sham, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Achilles-Day, Undine E.M., Morton, Leslie Hugh Glyn, Pearce, Mark and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2015) Risk assessment for the spread of Serratia marcescens within dental-unit waterline systems using Vermamoeba vermiformis. Current Microbiology, 71 (4). pp. 434-442.

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Harding, Alice, Poole, Sophie, Kesavalu, Lakshmyya and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2015) Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease. Mediators of Inflammation, 2015 (137357). ISSN 0962-9351

Turner, Martin, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Dennison, Sarah Rachel ORCID: 0000-0003-4863-9607, Morton, Leslie Hugh Glyn and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2015) Challenging the Clostridium botulinum toxin type A (BoNT/A) with a selection of microorganisms by culture methods and extended storage of used vials to assess the loss of sterility. Journal of Dental Applications, 2 (5). pp. 223-228. ISSN 2381-9049

Poole, Sophie, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Chukkapalli, Sasanka, Rivera, Mercedes, Velsko, Irina, Kesavalu, Lakshmyya and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2015) Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains. Journal of Alzheimer's Disease, 43 (1). pp. 67-80. ISSN 1387-2877

2014

Dillon, Amanda, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Achilles-Day, Undine EM, Pearce, Mark, Morton, Leslie Hugh Glyn and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2014) Vermamoeba vermiformis does not propagate Legionella pneumophila subsp. pascullei in a simulated laboratory dental-unit waterline system. International Biodeterioration & Biodegradation, 90 . pp. 1-7. ISSN 0964-8305

Lal, Sham, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Bricknell, Matt, Pearce, Mark, Morton, Leslie Hugh Glyn, Ahmed, Waqar ORCID: 0000-0003-4152-5172 and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2014) Monitoring Dental-Unit-Water-Line Output Water by Current In-office Test Kits. Current Microbiology, 69 (2). pp. 135-142.

Dillon, Amanda, Achilles-Day, Undine EH, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Pearce, Mark, Morton, Leslie Hugh Glyn and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2014) Biocide sensitivity of Vermamoeba vermiformis isolated from dental-unit-waterline systems. International Biodeterioration & Biodegradation, 88 . pp. 97-105. ISSN 0964-8305

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Harding, Alice, Simmons, Tal, Robinson, Sarita Jane ORCID: 0000-0002-4237-5412, Kesavalu, Lakshmyya and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2014) Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer’s Disease. Journal of Alzheimer's Disease, 42 (3). pp. 723-737. ISSN 1387-2877

2013

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 (2013) C1q, the classical complement pathway protein binds Hirano bodies in Pick's disease. Microscopy Research and Technique, 76 (6). pp. 606-611. ISSN 1059910X

Poole, Sophie, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Kesavalu, Lakshmyya, Curtis, Michael and Crean, Stjohn ORCID: 0000-0001-9336-8549 (2013) Determining the presence of periodontopathic virulence factors in short-term postmortem Alzheimer's disease brain tissue. Journal of Alzheimer's Disease, 36 (4). pp. 665-677. ISSN 13872877

2010

Agarwal, Sudha, Williams, Rebecca, Khan, Ilyas M., Richardson, Kirsty, Nelson, Larissa, McCarthy, Helen E., Analbelsi, Talal, Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Dowthwaite, Gary P. et al (2010) Identification and Clonal Characterisation of a Progenitor Cell Sub-Population in Normal Human Articular Cartilage. PLoS ONE, 5 (10). e13246-e13246. ISSN 1932-6203

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963 and Nair-Roberts, Radha G (2010) In situ hybridization and immunofluorescence on resin-embedded tissue to identify the components of Nissl substance. Microscopy Research and Technique, 73 (5). pp. 555-559. ISSN 1059910X

2009

Gilbert, Sophie J., Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Khan, Ilyas M., Gonzalez, Lee G., Thomson, Brian M., Burdon, Drew, Duance, Victor C. and Archer, Charles W. (2009) Enhanced Tissue Integration During Cartilage RepairIn VitroCan Be Achieved by Inhibiting Chondrocyte Death at the Wound Edge. Tissue Engineering Part A, 15 (7). pp. 1739-1749. ISSN 1937-3341

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Müller, CT, Gilbert, SJ, Duance, VC and Archer, CW (2009) An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New using fluorescein isothiocyanate secondary detection. Microscopy Research and Technique, 72 (7). pp. 501-506. ISSN 1059-910X

Singhrao, Simarjit Kaur ORCID: 0000-0001-9573-5963, Müller, Carsten T., Gilbert, Sophie J., Duance, Victor C. and Archer, Charles W. (2009) An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New® using fluorescein isothiocyanate secondary detection. Microscopy Research and Technique, 72 (7). pp. 501-506. ISSN 1059910X